At the Bioprocessing Amphacademy 2025, leading experts demonstrated how real-time, high-content cell analysis is transforming modern bioprocessing.
The program covered a wide spectrum of emerging approaches — from impedance flow cytometry for process understanding and scale-up, to automated online sampling concepts, metabolic state profiling, and advanced analytics for microbial and mammalian systems. Case studies highlighted how single-cell insights accelerate development, strengthen process control, and improve robustness in complex environments.
Recordings
Unlocking Biotechnology’s Potential at Scale
Massimo Portincaso – Arsenale Bioyards
Biotechnology is moving far beyond biopharma – but scaling it remains the biggest barrier. In his keynote, Massimo Portincaso shows how the integration of biology, engineering, data, and AI can unlock reliable, cost-effective biomanufacturing. Using Arsenale’s vision for an end-to-end precision-fermentation infrastructure, he outlines how a new industrial paradigm is emerging – one where nature becomes a true partner in large-scale production.
Characterisation of microalgal cultures by impedance flow cytometry – from dynamic complexity to single cell properties
Prof. Gerhard Obermeyer – Uni Salzburg
Microalgae are central to a green, circular economy – but monitoring their cultivation is still costly and labor-intensive. Gerhard Obermeyer shows how impedance flow cytometry enables fast, cost-efficient, single-cell insights into algal physiology and viability. Using Auxenochlorella protothecoides as a model, he demonstrates how impedance patterns reveal culture conditions and process status, opening new possibilities for scalable algae biotechnology.
From Cells to Scale: Navigating the Future of Industrial Bioprocessing
Furkan Gökçe – Amphasys
Bioprocessing is evolving rapidly, yet many challenges remain shared across applications — from scalable production and new microbial hosts to novel products, regulation, and sustainability. Furkan Gökce highlights these cross-industry hurdles and showcases emerging solutions such as automation, advanced monitoring, circular feedstocks, and new infrastructure models. His talk underscores why integration and collaboration are essential to turn innovation into real manufacturing impact.
The Challenges of Manufacturing Processes for Animal Cell-Based Cultured Food
Richard Alldread – The Cultured Hub
Cultured food production faces major technical, economic, and regulatory hurdles — from diverse cell lines and in-bioreactor behavior to unclear global standards. Richard Alldread outlines these challenges and presents how The Cultured Hub is building adaptable, cost-efficient platforms to accelerate development and scale in animal cell–based manufacturing.
Please note: For this session, we can only provide the slide deck, not the recording.
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Monitoring Next-Generation Protein Degrader Bioproduction with Impedance Flow Cytometry
Lorena Jukic – GlycoEra
Next-generation protein degraders require innovative production hosts and advanced analytics. GlycoEra uses Leishmania tarentolae to produce novel, human-like biologics — yet monitoring these unconventional cells is challenging with standard tools. Lorena Jukic shows how impedance flow cytometry enables precise cell counting and morphology tracking during bioprocess development, supporting the creation of cutting-edge extracellular protein degraders for autoimmune diseases.
Please note: For this session, we can only provide the slide deck, not the recording.
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Impedance Flow Cytometry Reveals Sublethal Single-Cell Effects and Morphological Changes Induced by Ceftazidime and Bacteriophages in Pseudomonas aeruginosa
Lukas Neutsch – ZHAW
As antimicrobial resistance rises globally, new analytical tools are needed to optimize Phage-Antibiotic-Synergy (PAS). This study showcases how impedance flow cytometry (IFC) provides rapid, label-free, single-cell insights into the effects of Ceftazidime, phages, and their combination against P. aeruginosa. IFC sensitively detects early physiological changes such as filamentation, offering a powerful platform for real-time phenotyping and improved bioprocess monitoring in phage therapy development.
Closing the Loop: Automated, Real-time, In-process Monitoring of Microbial Cell Cultures
Marco Di Berardino – Amphasys
Microbial cultures are highly dynamic and heterogeneous, making real-time monitoring challenging with traditional tools. Marco Di Berardino presents a new concept for automated, high-content microbial analysis that integrates on-line sampling and dilution with label-free single-cell measurements. This closed-loop setup enables continuous tracking of key parameters such as size, viability, concentration, and metabolic status — and opens the door to further automation, including product monitoring, for fully integrated and efficient bioprocesses.
SAVE THE DATE FOR AMPHACADEMY 2026
19.11.2026
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